MOTS-C

MOTS-c is a sixteen-residue peptide encoded within the 12S ribosomal RNA region of mitochondrial DNA, first described in 2015. Its identification supported a broader idea: that mitochondria signal to the rest of the cell using peptides, not only metabolites. Under metabolic stress it has been reported to translocate to the nucleus, which would make it a direct organelle-to-nucleus messenger.

MOTS-C is a mitochondrial-derived research peptide referenced in laboratory studies of metabolic homeostasis and cellular-energy signaling. It is used in controlled research models examining AMPK-pathway activity and metabolic-stress-response mechanisms. Within preclinical frameworks, MOTS-C is investigated for its role in nuclear-mitochondrial signaling communication and metabolic-regulation pathways within controlled laboratory environments.

Strictly for in-vitro, cell-based, and preclinical laboratory research applications. No therapeutic, diagnostic, or clinical claims are made or implied.

• Mitochondrial Signaling Studies — Investigation of mitochondrial-derived peptide signaling and metabolic-stress response in controlled models.
• AMPK-Pathway Research — Experimental study of AMPK-associated metabolic-signaling activity in preclinical systems.
• Metabolic-Homeostasis Analysis — Research examining cellular-energy regulation and homeostatic signaling within laboratory frameworks.
• Nuclear-Mitochondrial Communication Models — Evaluation of nuclear-mitochondrial signaling coordination under controlled conditions.

What is MOTS-C used for?
MOTS-C is supplied for laboratory and preclinical research involving mitochondrial signaling, metabolic-homeostasis pathways, and cellular-energy mechanisms. It is not intended for human or veterinary use, therapeutic application, or diagnostic purposes.

Who is eligible to purchase MOTS-C?
MOTS-C is sold exclusively to qualified researchers and licensed laboratories. By purchasing, buyers confirm they are knowledgeable in handling research-use-only (RUO) materials and will use the product in compliance with applicable regulations.

Is MOTS-C approved for human or veterinary use?
No. This product is supplied strictly as a research material and is not approved for human or veterinary use, ingestion, diagnosis, or treatment of any condition.

What purity and quality standards are used?
Each batch is manufactured to high-purity standards and undergoes analytical verification and quality-control review. A batch-specific Certificate of Analysis (COA) is provided to document identity, purity, and applicable testing.

How should MOTS-C be stored and handled?
It should be stored under controlled laboratory conditions, protected from heat, moisture, and direct light, and handled following standard laboratory protocols for research materials. Where applicable, avoid repeated freeze-thaw cycles.

Why does the vial appear nearly empty?
Research materials are supplied by analytical mass rather than visible volume. Contents may appear minimal within the container while still meeting the labeled specifications. This is normal for high-purity research materials.

Is documentation provided with each order?
Yes. Each batch is accompanied by a batch-specific Certificate of Analysis (COA) and supporting documentation to support quality assurance, batch traceability, and recordkeeping.

Can MOTS-C be used in combination studies?
In laboratory settings, MOTS-C may be evaluated alongside other research materials as part of structured experimental study designs. Any combination research should be conducted under controlled laboratory conditions and established analytical research protocols.

For laboratory and research use only. Not for human or veterinary use or consumption. Sold only to qualified researchers.

A Certificate of Analysis is issued for every lot and matched to the lot number printed on your vial. Identity is confirmed by mass spectrometry and purity by HPLC, with third-party ISO-accredited verification available on request. A Safety Data Sheet (SDS) is available for every product.

Orders are processed and shipped promptly via tracked courier. Materials ship lyophilized and remain stable in transit; on arrival, store as indicated on the vial — typically refrigerated or frozen and protected from light — for maximum stability.

See our Shipping & Returns policy for full details.